Rik was born in 1963 in The Netherlands and obtained an MSc (Cum Laude) in Biology with a specialisation in Theoretical Biology from the Free University of Amsterdam in 1987. He worked as modeller and statistician at the Reproductive Endocrinology and Fertility Research outpatient clinic at the Free University Hospital in Amsterdam from 1987-1989 after which he joined the Centre for Human Drug Research (CHDR) in Leiden from 1989-2007. At CHDR he worked as statistician, pharmacokineticist and mathematical modeller, and was involved in all aspects of early phase drug development. While at CHDR, he obtained his PhD on Modelling Repeated Measurements in Clinical Pharmacology in 1999. In 2000 he became a Registered Biostatistician of the Netherlands Society for Statistics and Operations Research (VVS). Rik subsequently worked at Exprimo from 2007-2015 as senior consultant, hugely expanding his modelling and simulation skills, running over 20 full-scale projects for a range of clients with applications in scaling adult to paediatric PK and PK/PD, tumour growth modelling, adverse event and effect modelling using repeated ordered categorical data, viral dynamics modelling, modelling repeated daily seizure counts in epilepsy, and naturally numerous population pharmacokinetic projects. In 2015, he co-founded Occams Coöperatie U.A. that provides pharmacokinetic and pharmacodynamic modelling and simulation services to drug development programs. He is author and co-author of over 180 publications, including a number of original research articles in the field of PK/PD modelling. Rik has been actively involved in organising the PAGE meeting from 1996 to 2019, is an active member of the nlmixr development team since 2015, and additionally develops tools to aid in automatic report generation. Rik lives in The Netherlands.
Rik is the 2017 recipient of the International Society of Pharmacometrics (ISoP) Leadership Award, which recognizes outstanding and sustained leadership, mentorship, and outreach contributions to the field of pharmacometrics and to the development of the strategic vision for the future direction of the field.